Dilated Cardiomyopathy (DCM)
DCM is one of the more common form of Cardiomyopathy, where the walls of the heart become thin and weakened, enlarging the heart and resulting in congestive heart failure. There are several possible causes to this problem including environmental and physiological factors as well as genetic predisposition.
Symptoms: Coughing, shortness of breath, exercise intolerance or collapse, weakness, lethargy, restlessness, anorexia.
Treatment Options: Early and regular screening should be done to detect any abnormal heart sounds. In the case of an affected individual, a complete analysis may be required to rule out any other causes and get a more accurate diagnosis.
Symptoms may be controlled by prescribed oral medications, but unfortunately prognosis is poor with a very high mortality rate.
Known Mode of Inheritance: Unknown in Cardigans. Thought to be Autosomal Dominant in Boxers and possibly gender linked in Great Danes. Currently it is considered a complex issue with genetic predisposition.
Age of onset: 4-10 years, typically seen in older dogs.
- Cardigan: yes
- Pembroke: yes
- Other Breeds: yes, many breeds and mixed breeds, but Boxers, Dobermans, Newfoundlands and Great Danes have been identified at greater risk.
Incidence in Cardigans: Uncertain due to low participation in testing. OFA Cardiac Statistics ranks cardigans 83rd out of the 133 breeds with more than 50 individuals submitted to their database. Out of the 57 cardigans in the OFA Cardiac registry, none are identified as affected by this problem. Incidence may be relatively low, but it has been reported in the breed.
- Cardigans: no
- Other breeds: yes. primarily for Dobermans, Newfoundlands, Great Danes and Boxers.
- Active?: yes
Registry: yes, the OFA has a Cardiac Database which is currently being improved.
DNA Tests Available: not currently. A marker has been identified in Dobermans, but at this time 15 percent of affected individuals tested do not carry this defect, so further research is in progress.
Published papers and Articles:
- A Locus on Chromosome 5 Is Associated with Dilated Cardiomyopathy in Doberman Pinschers
- Evaluation of candidate genes for X — linked dilated cardiomyopathy in the Great Dane
- Inheritance Patterns and Molecular Genetic Analysis of Doberman Pinschers and Boxer Dogs with Familial Dilated Cardiomyopathy
- Diet-Related Taurine Deficiency in Newfoundland Dogs and Associated Cardiac Insufficiency
- Canine dilated cardiomyopathy: a retrospective study of prognostic findings in 367 clinical cases.
- Genome-wide association identifies a deletion in the 3’ untranslated region of Striatin in a canine model of arrhythmogenic right ventricular cardiomyopathy
- Human research: Truncations of titin causing dilated cardiomyopathy.
- Cleft palate, retrognathia and congenital heart disease in velo-cardio-facial syndrome: a phenotype correlation study.
- Yahoo group: DogHeart